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Category Archives: hippocampus
I never meant to study the brainstem
I was recently invited to contribute a guest post on Substack by Vijay Iyer – some years ago one of the main developers of ScanImage in the lab of Karel Svoboda, and more recently a strong advocate for ME/CFS awareness … Continue reading
Posted in Astrocytes, Brain machine interface, Calcium Imaging, hippocampus, Locus coeruleus, Microscopy, writing
Tagged arousal, brain, Calcium Imaging, Microscopy, neuroscience, photons, science, stress
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Displaying the hippocampus as EM image on the office wall
One of the most amazing methods in modern neuroscience is dense volumetric electron microscopy of the brain. I have mentioned some openly accessible datasets before (see my previous blog post), but many additional datasets have been released since then – … Continue reading
Posted in Data analysis, hippocampus, Imaging, Microscopy, Network analysis, neuroscience
Tagged Data analysis, Microscopy
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Interesting papers on the role of cell organelles of neuronal dendrites in calcium signaling
Researchers utilize calcium imaging to track neuronal activity in the brain, highlighting the role of calcium as a signaling molecule. Recent studies investigate intracellular calcium dynamics, particularly its coupling between organelles and its influence on synaptic plasticity in dendrites. Findings emphasize the necessity of in vivo methods for accurate insights into neuronal behavior. Continue reading
Posted in Calcium Imaging, Data analysis, hippocampus, Microscopy, neuroscience, Reviews
Tagged Calcium Imaging, Microscopy
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Interesting papers on VIP interneurons in cortex and hippocampus
Interneurons are inhibitory neurons in the brain that are thought to shape the computations performed by principal cells. The effects of inhibition can be rather diverse, depending on which neurons – or which parts of a neuron (dendrites, soma, or … Continue reading
Posted in Calcium Imaging, Data analysis, hippocampus, Imaging, Neuronal activity, neuroscience, Reviews
Tagged Calcium Imaging, Data analysis
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Open PhD position in my research group
Are you a finishing Master’s student with a quantitative background and are interested in neuroscience? This is your opportunity. Project: You will be supervised by Dr. Peter Rupprecht and Prof. Fritjof Helmchen at the Brain Research Institute, University of Zurich. … Continue reading
How to compute ΔF/F from calcium imaging data
Many neuroscientists use calcium imaging to record the activity from neurons (or other cells in the brain). The video below was recorded by Sian Duss and me in hippocampal CA1 pyramidal cells in mice. To make calcium imaging traces comparable … Continue reading
Posted in Calcium Imaging, Data analysis, hippocampus, Imaging, Microscopy, neuroscience
Tagged Calcium Imaging, Data analysis
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Four interesting papers on astrocyte physiology
A review of four interesting recent papers on astrocyte neuroscience: (1) Norepinephrine Signals Through Astrocytes To Modulate Synapses (2) A spatial threshold for calcium surge (3) Network-level encoding of local neurotransmitters in cortical astrocytes, and (4) Continue reading
Posted in Calcium Imaging, Data analysis, hippocampus, Imaging, Microscopy, Neuronal activity, neuroscience, Reviews, zebrafish
Tagged Calcium Imaging, Data analysis, Microscopy, zebrafish
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There is no recipe for discoveries
There is no recipe for discoveries, and there is no cookbook on how to publish a paper. But at least there are typical events and routes that are often encountered. Here, I’d like to share the trajectory of a study … Continue reading
Posted in Calcium Imaging, Data analysis, hippocampus, Imaging, machine learning, Microscopy, neuroscience, Review
Tagged Calcium Imaging, Data analysis, Microscopy
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Why your two-photon images are noisier than you expect
A gallery of calcium imaging recordings of neurons and astrocytes with single noisy frames on the left and averaged beautiful noise-free images on the right side. Continue reading
Posted in Calcium Imaging, Data analysis, hippocampus, Imaging, Microscopy, Neuronal activity, neuroscience, zebrafish
Tagged Calcium Imaging, Data analysis, Microscopy, photons, Scanning, zebrafish
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Annual report of my intuition about the brain (2023)
How does the brain work and how can we understand it? To view this big question from a broad perspective, I’m reporting some ideas about the brain that marked me most during the past twelve months and that, on the … Continue reading
Posted in hippocampus, Neuronal activity, Review
Tagged evolution, language, theoretical neuroscience
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A blog about neurophysiology 