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Author Archives: P.T.R. Rupprecht
Annual report of my intuition about the brain (2022)
How does the brain work and how can we understand it? To view this big question from a broad perspective at the end of each year, I’m reporting some of the thoughts about the brain that marked me most during … Continue reading
“Laser Scanners” by William Benner
William Benner is a scanner enthusiast and the president of the company Pangolin. His company sells equipment mostly for laser shows but also for other applications. Some years ago, he wrote a book on “Laser Scanners”, which is available through … Continue reading
Ambizione fellowship and an open PhD position
I’m glad to share that I am going to start my own junior research group at the University of Zurich in March 2023! As an Ambizione fellow, I will receive funding for my own salary, some equipment, consumables and a … Continue reading
Post-publication review: The geometry of robustness in spiking neural networks
Selected paper: Calaim, Dehmelt, Gonçalves and Machens, The geometry of robustness in spiking neural networks, eLife (2022) The main message: This theoretical neuroscience paper describes an intuitive way how to think about the effect of single spikes in a network … Continue reading
Posted in Network analysis, Neuronal activity, Reviews
Tagged theoretical neuroscience
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Self-supervised denoising of calcium imaging data
This blog post is about algorithms based on deep networks to denoise raw calcium imaging movies. More specifically, I will write about the difficulties to interprete their outputs, and on how to address these limitations in future work. I will … Continue reading
Video introduction to CASCADE
A video with tutorial on CASCADE, a supervised method to infer spike rates from calcium imaging data. Continue reading
Simple geometrical optics to understand and design point-scanning microscopes
Custom-built microscopes have become more and more sophisticated over the last years to provide a larger FOV, better resolution through some flavor of adaptive optics or simply more neurons simultaneously. Professional optical engineers are hired to design the ideal lens … Continue reading
Public peer review files
Peer-review is probably the most obscure part of the publication of scientific results. In this blog post, I would like to make the point that the best way to learn about it – except by being directly involved – is … Continue reading
Posted in Calcium Imaging, Imaging, machine learning, Microscopy, Neuronal activity, Review
Tagged deep learning, Microscopy, neuroscience, peer review
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Annual report of my intuition about the brain (2021)
How does the brain work and how can we understand it? I want to make it a habit to report some of the thoughts about the brain that marked me most during the past twelve month at the end of … Continue reading
Large-scale calcium imaging & noise levels
Calcium imaging based on two-photon scanning microscopy is a standard method to record the activity of neurons in the living brain. Due to the point-scanning approach, sampling speed is limited and the dwell time on a single neuron reduces with … Continue reading
Posted in Calcium Imaging, Data analysis, Imaging, Microscopy, Neuronal activity
Tagged Calcium Imaging, Data analysis, Microscopy, photons, Scanning
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A blog about neurophysiology 