Category Archives: machine learning

Public peer review files

Peer-review is probably the most obscure part of the publication of scientific results. In this blog post, I would like to make the point that the best way to learn about it – except by being directly involved – is … Continue reading

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Annual report of my intuition about the brain (2021)

How does the brain work and how can we understand it? I want to make it a habit to report some of the thoughts about the brain that marked me most during the past twelve month at the end of … Continue reading

Posted in machine learning, Network analysis, Review | Tagged , , , | 3 Comments

5 reasons why to use Cascade for spike inference

Our paper on A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging is out now in Nature Neuroscience. It consists of a large and diverse ground truth database with simultaneous calcium imaging and juxtacellular recordings … Continue reading

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Online spike rate inference with Cascade

To infer spike rates from calcium imaging data for a time point t, knowledge about the calcium signal both before and after time t is required. Our algorithm Cascade (Github) uses by default a window that is symmetric in time … Continue reading

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Temporal dispersion of spike rates from deconvolved calcium imaging data

On Twitter, Richie Hakim asked whether the toolbox Cascade for spike inference (preprint, Github) induces temporal dispersion of the predicted spiking activity compared to ground truth. This kind of temporal dispersion had been observed in a study from last year … Continue reading

Posted in Calcium Imaging, Data analysis, machine learning, Microscopy, Neuronal activity | Tagged , , | 1 Comment

Annual report of my intuition about the brain (2020)

How does the brain work and how can we understand it? I want to make it a habit to report some of the thoughts about the brain that marked me most during the past twelve month at the end of … Continue reading

Posted in Data analysis, machine learning, Network analysis, Neuronal activity, Reviews | Tagged , , , | 3 Comments

Simultaneous calcium imaging and extracellular recording from the same neuron

Calcium imaging is a powerful method to record from many neurons simultaneously. But what do the recorded signals really mean? This question can only be properly addressed by experiments which record both calcium signals and action potentials from the same … Continue reading

Posted in Calcium Imaging, Data analysis, electrophysiology, machine learning, Microscopy, Neuronal activity, zebrafish | Tagged , , , , | Leave a comment

Annual report of my intuition about the brain (2019)

How does the brain work and how can we understand it? I want to make it a habit to report some of the thoughts about the brain that marked me most during the past twelve month at the end of … Continue reading

Posted in Calcium Imaging, Data analysis, electrophysiology, machine learning, Network analysis, Neuronal activity, Review | Tagged , , , , , , , | 8 Comments

Annual report of my intuition about the brain

There are not many incentives for young neuroscientists to think aloud about big questions. Due to lack both of knowledge and authority, discussing very broad questions like how the brain works risks to be embarrassing at best. Still, I feel … Continue reading

Posted in Calcium Imaging, electrophysiology, machine learning, Neuronal activity | Tagged , , , , | 4 Comments

Entanglement of temporal and spatial scales in the brain, but not in the mind

In physics, many problems can be solved by a separation of scales and thereby become tractable. For example, let’s have a look at surface waves on water: they are rather easy to understand when the water wave-length is much larger … Continue reading

Posted in Data analysis, machine learning, Network analysis | Tagged , , , , | 2 Comments