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Author Archives: P.T.R. Rupprecht
Four interesting papers on astrocyte physiology
A review of four interesting recent papers on astrocyte neuroscience: (1) Norepinephrine Signals Through Astrocytes To Modulate Synapses (2) A spatial threshold for calcium surge (3) Network-level encoding of local neurotransmitters in cortical astrocytes, and (4) Continue reading
Posted in Calcium Imaging, Data analysis, hippocampus, Imaging, Microscopy, Neuronal activity, neuroscience, Reviews, zebrafish
Tagged Calcium Imaging, Data analysis, Microscopy, zebrafish
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There is no recipe for discoveries
There is no recipe for discoveries, and there is no cookbook on how to publish a paper. But at least there are typical events and routes that are often encountered. Here, I’d like to share the trajectory of a study … Continue reading
Posted in Calcium Imaging, Data analysis, hippocampus, Imaging, machine learning, Microscopy, neuroscience, Review
Tagged Calcium Imaging, Data analysis, Microscopy
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Why your two-photon images are noisier than you expect
A gallery of calcium imaging recordings of neurons and astrocytes with single noisy frames on the left and averaged beautiful noise-free images on the right side. Continue reading
Posted in Calcium Imaging, Data analysis, hippocampus, Imaging, Microscopy, Neuronal activity, neuroscience, zebrafish
Tagged Calcium Imaging, Data analysis, Microscopy, photons, Scanning, zebrafish
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Three recent interesting papers on computational neuroscience
Three papers:
1. The Neuron as a Direct Data-Driven Controller
2. A learning algorithm beyond backpropagation
3. Continuous vs. discrete representations in a recurrent network Continue reading
Annual report of my intuition about the brain (2023)
How does the brain work and how can we understand it? To view this big question from a broad perspective, I’m reporting some ideas about the brain that marked me most during the past twelve months and that, on the … Continue reading
Posted in hippocampus, Neuronal activity, Review
Tagged evolution, language, theoretical neuroscience
6 Comments
Useful pieces from Twitter
Twitter used to be (and still is to some extent) a source of useful information for neuroscientists about technical details, clarifications of research findings and open discussions that cannot be obtained so easily otherwise. Here is a list of some … Continue reading
Posted in Data analysis, electrophysiology, Links, machine learning, Microscopy
Tagged Data analysis, electrophysiology, Microscopy
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Improving the resonant scanner’s sync signal using a phase locked loop (PLL)
Calcium imaging with two-photon point scanning is the technique to chronically record from identified neurons in the living brain of animals. The central piece of two-photon point scanning microscopes is a scan engine. This can be a complex optical device … Continue reading
Posted in Calcium Imaging, Imaging, Microscopy, neuroscience
Tagged Microscopy, photons, Scanning
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Two random but interesting papers on neurophysiology with behavior
Bagur, Bourg et al. (2022) from the Bathellier Lab in Paris make the interesting finding that the auditory code is represented as temporal sequences of neuronal activity in early auditory processing stages and as spatial patterns in auditory cortex. I … Continue reading
Interesting papers on behavioral timescale synaptic plasticity (theory)
Behavioral timescale synaptic plasticity (BTSP) is a form of single-shot learning observed in hippocampal place cells in mice (Bittner et al., 2015, 2017). This finding is both interesting and inspiring for computational neuroscience for several reasons. In the first place, … Continue reading
Interesting papers on behavioral timescale synaptic plasticity (experiments)
Behavioral timescale synaptic plasticity (BTSP) is a form of single-shot learning observed in hippocampal place cells in mice (Bittner et al., 2015, 2017). The idea is that post-synaptic activations (“eligibility traces”) are potentiated by a dendritic plateau potential/burst (“instructive signal”) … Continue reading
A blog about neurophysiology 