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Interesting papers on astrocyte ultrastructure and function
Astrocytes are brain cells that are often completely overlooked and dismissed or, in the opposite extreme, presented as mysterious devices that somehow solve all problems of computational neuroscience. The truth is somewhere in the middle, but it is not clear yet where exactly. First of all, we still do not understand even the basic mechanistic rules by which individual astrocytes operate. For neurons, we have precise, often even mathematical ideas how they receive input via synapses, how they depolarize, and how depolarizations propagate to the soma and elicit action potentials. For astrocytes, this mechanistic book of rules is still missing – and this gap limits our ability to interpret experiments or build coherent theories. Continue reading
Posted in Astrocytes, Calcium Imaging, Data analysis, Microscopy, neuroscience, Reviews
Tagged Calcium Imaging, Microscopy, neuroscience, science
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I never meant to study the brainstem
I was recently invited to contribute a guest post on Substack by Vijay Iyer – some years ago one of the main developers of ScanImage in the lab of Karel Svoboda, and more recently a strong advocate for ME/CFS awareness … Continue reading
Posted in Astrocytes, Brain machine interface, Calcium Imaging, hippocampus, Locus coeruleus, Microscopy, writing
Tagged arousal, brain, Calcium Imaging, Microscopy, neuroscience, photons, science, stress
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How to use Google Scholar as a neuroscientist
Google Scholar is a search engine for scientific publications. There are alternatives like PubMed (not a search engine but a database, often used in the medical field), Semantic Scholar (also a database, but with richer annotations), Citation Gecko (to discover … Continue reading
Posted in neuroscience, Review, Reviews, writing
Tagged Literature search, neuroscience, science
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Annual report of my intuition about the brain (2024)
The brain is a complex system that cannot be understood by a strictly structured approach. Knowledge must grow organically, and a systematic approach can sometimes hinder understanding. In formal education, this truth is often hidden because curricula and instructors provide the structuring of knowledge already. But when it comes to acquiring new knowledge and insight, rather than merely processing and assembling pre-existing knowledge, this systematic approach must be continuously interrupted and re-invented to enable real progress. Continue reading
Posted in Data analysis, Neuronal activity, neuroscience, Reviews
Tagged brain, neuroscience, research, science, theoretical neuroscience, writing
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A resource paper for building two-photon microscopes
The article discusses the challenges in learning to build microscopes, highlighting a manuscript by Schottdorf et al. that offers practical assembly instructions and rationale based on years of successful use. It emphasizes useful insights, such as design suggestions, performance compromises, and comprehensive documentation on GitHub, making it a valuable resource for researchers. Continue reading
Posted in Calcium Imaging, Imaging, Microscopy, neuroscience
Tagged Calcium Imaging, Microscopy, neuroscience, papers, photons, Scanning, science
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