Tag Archives: neuroscience

Interesting papers on astrocyte ultrastructure and function

Astrocytes are brain cells that are often completely overlooked and dismissed or, in the opposite extreme, presented as mysterious devices that somehow solve all problems of computational neuroscience. The truth is somewhere in the middle, but it is not clear yet where exactly. First of all, we still do not understand even the basic mechanistic rules by which individual astrocytes operate. For neurons, we have precise, often even mathematical ideas how they receive input via synapses, how they depolarize, and how depolarizations propagate to the soma and elicit action potentials. For astrocytes, this mechanistic book of rules is still missing – and this gap limits our ability to interpret experiments or build coherent theories. Continue reading

Posted in Astrocytes, Calcium Imaging, Data analysis, Microscopy, neuroscience, Reviews | Tagged , , , | Leave a comment

I never meant to study the brainstem

I was recently invited to contribute a guest post on Substack by Vijay Iyer – some years ago one of the main developers of ScanImage in the lab of Karel Svoboda, and more recently a strong advocate for ME/CFS awareness … Continue reading

Posted in Astrocytes, Brain machine interface, Calcium Imaging, hippocampus, Locus coeruleus, Microscopy, writing | Tagged , , , , , , , | Leave a comment

Open PhD position in my research group

Are you a finishing Master’s student with a quantitative background and are interested in neuroscience? This is your opportunity. Project: You will be supervised by Dr. Peter Rupprecht and Prof. Fritjof Helmchen at the Brain Research Institute, University of Zurich. … Continue reading

Posted in Calcium Imaging, Data analysis, hippocampus, Imaging, machine learning, Microscopy, Neuronal activity, neuroscience | Tagged , , , , , | Leave a comment

How to use Google Scholar as a neuroscientist

Google Scholar is a search engine for scientific publications. There are alternatives like PubMed (not a search engine but a database, often used in the medical field), Semantic Scholar (also a database, but with richer annotations), Citation Gecko (to discover … Continue reading

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Annual report of my intuition about the brain (2024)

The brain is a complex system that cannot be understood by a strictly structured approach. Knowledge must grow organically, and a systematic approach can sometimes hinder understanding. In formal education, this truth is often hidden because curricula and instructors provide the structuring of knowledge already. But when it comes to acquiring new knowledge and insight, rather than merely processing and assembling pre-existing knowledge, this systematic approach must be continuously interrupted and re-invented to enable real progress. Continue reading

Posted in Data analysis, Neuronal activity, neuroscience, Reviews | Tagged , , , , , | 6 Comments

A resource paper for building two-photon microscopes

The article discusses the challenges in learning to build microscopes, highlighting a manuscript by Schottdorf et al. that offers practical assembly instructions and rationale based on years of successful use. It emphasizes useful insights, such as design suggestions, performance compromises, and comprehensive documentation on GitHub, making it a valuable resource for researchers. Continue reading

Posted in Calcium Imaging, Imaging, Microscopy, neuroscience | Tagged , , , , , , | 1 Comment

The idea for a journal “eLife-A”

The process of publishing and reviewing scientific results is often a strange and difficult-to-navigate landscape. It would take too long to mention all the problems and pitfalls related to publishing. For example: overly high publication charges; long turnaround times for … Continue reading

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Public peer review files

Peer-review is probably the most obscure part of the publication of scientific results. In this blog post, I would like to make the point that the best way to learn about it – except by being directly involved – is … Continue reading

Posted in Calcium Imaging, Imaging, machine learning, Microscopy, Neuronal activity, Review | Tagged , , , | 2 Comments